Cavity effects on the Fermi velocity renormalization in a graphene sheet

Recently, in the literature, it was shown that the logarithmic renormalization of the Fermi velocity in a plane graphene sheet (which, in turn, is related to the Coulombian static potential associated to electrons in the sheet) is inhibited by the presence of a single parallel conducting plate. In the present paper, we investigate the situation of a suspended graphene sheet in a cavity formed by two conducting plates parallel to the sheet. The effect of a cavity on the interaction between electrons in the graphene is not merely the addition of the effects of each plate individually. From this, one can expect that the inhibition of the renormalization of the Fermi velocity generated by a cavity is not a mere addition of the inhibition induced by each single plate. In other words, the simple addition of the result for the inhibition of the renormalization of the Fermi velocity found in the literature for a single plate could not be used to predict the exact behavior of the inhibition for the graphene between two plates. Here, we show that, in fact, this is what happens and calculate how the presence of a cavity formed by two conducting plates parallel to the suspended graphene sheet amplifies, in a non-additive manner, the inhibition of the logarithmic renormalization of the Fermi velocity. In the limits of a single plate and no plates, our formulas recover those found in the literature.This work was partially supported by the following Brazilian Agencies: Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES), Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), and Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ). E. C. Marino was partially supported by CNPq and FAPERJ. D. T. Alves was partially supported by CAPES via Programa Estagio Senior no Exterior - Processo 88881.119705/2016-01, by CNPq via Processos 461826/2014-3 (Edital Universal) and 311920/2014-4 (Bolsa de Produtividade em Pesquisa), and also thanks Jaime Santos, Mikhail I. Vasilevskiy, Nuno M. R. Peres and Yuliy Bludov for useful discussions, as well as the hospitality of the Centro de Fisica, Universidade do Minho, Braga - Portugal. V. S. Alves acknowledges CNPq for support through Bolsa de Produtividade em Pesquisa n. 312654/2017-0. The authors also thank Ygor P. Silva for useful comments

Consensus Paper: Radiological Biomarkers of Cerebellar Diseases

Hereditary and sporadic cerebellar ataxias represent a vast and still growing group of diseases whose diagnosis and differentiation cannot only rely on clinical evaluation. Brain imaging including magnetic resonance (MR) and nuclear medicine techniques allows for characterization of structural and functional abnormalities underlying symptomatic ataxias. These methods thus constitute a potential source of radiological biomarkers, which could be used to identify these diseases and differentiate subgroups of them, and to assess their severity and their evolution. Such biomarkers mainly comprise qualitative and quantitative data obtained from MR including proton spectroscopy, diffusion imaging, tractography, voxel-based morphometry, functional imaging during task execution or in a resting state, and from SPETC and PET with several radiotracers. In the current article, we aim to illustrate briefly some applications of these neuroimaging tools to evaluation of cerebellar disorders such as inherited cerebellar ataxia, fetal developmental malformations, and immune-mediated cerebellar diseases and of neurodegenerative or early-developing diseases, such as dementia and autism in which cerebellar involvement is an emerging feature. Although these radiological biomarkers appear promising and helpful to better understand ataxia-related anatomical and physiological impairments, to date, very few of them have turned out to be specific for a given ataxia with atrophy of the cerebellar system being the main and the most usual alteration being observed. Consequently, much remains to be done to establish sensitivity, specificity, and reproducibility of available MR and nuclear medicine features as diagnostic, progression and surrogate biomarkers in clinical routine

The polymorphism L412F in TLR3 inhibits autophagy and is a marker of severe COVID-19 in males

The polymorphism L412F in TLR3 has been associated with several infectious diseases. However, the mechanism underlying this association is still unexplored. Here, we show that the L412F polymorphism in TLR3 is a marker of severity in COVID-19. This association increases in the sub-cohort of males. Impaired macroautophagy/autophagy and reduced TNF/TNFα production was demonstrated in HEK293 cells transfected with TLR3L412F-encoding plasmid and stimulated with specific agonist poly(I:C). A statistically significant reduced survival at 28 days was shown in L412F COVID-19 patients treated with the autophagy-inhibitor hydroxychloroquine (p = 0.038). An increased frequency of autoimmune disorders such as co-morbidity was found in L412F COVID-19 males with specific class II HLA haplotypes prone to autoantigen presentation. Our analyses indicate that L412F polymorphism makes males at risk of severe COVID-19 and provides a rationale for reinterpreting clinical trials considering autophagy pathways. Abbreviations: AP: autophagosome; AUC: area under the curve; BafA1: bafilomycin A1; COVID-19: coronavirus disease-2019; HCQ: hydroxychloroquine; RAP: rapamycin; ROC: receiver operating characteristic; SARS-CoV-2: severe acute respiratory syndrome coronavirus 2; TLR: toll like receptor; TNF/TNF-α: tumor necrosis factor

The LOFT mission concept: a status update

The Large Observatory For x-ray Timing (LOFT) is a mission concept which was proposed to ESA as M3 and M4 candidate in the framework of the Cosmic Vision 2015-2025 program. Thanks to the unprecedented combination of effective area and spectral resolution of its main instrument and the uniquely large field of view of its wide field monitor, LOFT will be able to study the behaviour of matter in extreme conditions such as the strong gravitational field in the innermost regions close to black holes and neutron stars and the supra-nuclear densities in the interiors of neutron stars. The science payload is based on a Large Area Detector (LAD, >8m2 effective area, 2-30 keV, 240 eV spectral resolution, 1 degree collimated field of view) and a Wide Field Monitor (WFM, 2-50 keV, 4 steradian field of view, 1 arcmin source location accuracy, 300 eV spectral resolution). The WFM is equipped with an on-board system for bright events (e.g., GRB) localization. The trigger time and position of these events are broadcast to the ground within 30 s from discovery. In this paper we present the current technical and programmatic status of the mission